When stopping acetaminophen/butalbital/caffeine that has been taken long-term, taper the dose down and discontinue slowly over 2 to 4 weeks. May cause medication-overuse headache with repeated use (more than 3 days per month) and a withdrawal syndrome (symptoms include worsened headache, nausea/vomiting, restlessness, anxiety, disturbed sleep, and sweating) upon discontinuation.It can cause drowsiness, sedation, hypnosis, and dose-dependent respiratory depression and is not considered a first-choice medicine for headaches. Butalbital is habit-forming and there is a high risk of dependence with extended and repeated use of acetaminophen/butalbital/caffeine.Taken every four hours as needed but use should not exceed 6 tablets or capsules daily.Other side effects, such as constipation, excessive sweating, itch, and mental confusion are less common.Dizziness, drowsiness, lightheadedness, sedation, shortness of breath, nausea, vomiting, abdominal pain, or an intoxicated feeling are the most commonly reported side effects.If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Generic acetaminophen/butalbital/caffeine is available.Available as capsules, tablets, and an oral solution.May be used short-term to relieve occasional tension or muscle contraction headaches.It may also be called a combination analgesic. Acetaminophen/butalbital/caffeine belongs to the class of medicines known as barbiturates because it contains butalbital.In addition, it has vasoconstrictive properties, narrowing blood vessels in the brain thereby decreasing blood flow and oxygen tension (before a headache or a migraine, blood vessels tend to enlarge). Caffeine is thought to enhance the pain-relieving effects of acetaminophen by up to 40%.When used for pain due to tension headaches, experts believe it works by relaxing muscle contractions and causing sedation via an enhancement of the inhibitory effects of GABA (a neurotransmitter that regulates communication between brain cells). Butalbital belongs to the class of medicines called barbiturates.Inhibition of the hypothalamic heat-regulating center gives acetaminophen its fever-lowering effect. Experts aren't sure exactly how acetaminophen works, but suspect it may activate descending serotonergic inhibitory pathways in the CNS and other nociceptive pathways (nociceptive pain describes pain from physical or potential damage to the body such as that from a sports injury or dental procedure).Acetaminophen/butalbital/caffeine is a combination pain-reliever (analgesic) containing acetaminophen, butalbital, and caffeine.Medically reviewed by Carmen Fookes, BPharm. Acetaminophen/butalbital/caffeine: 7 things you should know
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